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Sincalide ammonium

Sincalide ammonium
Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography.
Catalog No. TP1198Cas No. 70706-98-8
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Purity:98.46%
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Sincalide ammonium

Purity: 98.46%
Catalog No. TP1198Alias SQ19844 ammonium, Cholecystokinin octapeptide ammonium, CCK-8 ammoniumCas No. 70706-98-8

Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography.
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Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$247In Stock
10 mg$397In Stock
25 mg$652In Stock
50 mg$913In Stock
100 mg$1,230In Stock
500 mg$2,460In Stock
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Product Introduction

Bioactivity
Description
Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography.
In vitro
Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, functions as a novel cardiovascular hormone with a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. It also exhibits a positive role in combating inflammation, apoptosis, and collagen deposition. In the context of H9c2 cardiomyoblasts, CCK‐8 (ammonium) protects cells from Ang II-induced apoptosis, partly through the activation of the CCK1 receptor and the phosphatidylinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway[4].
In vivo
In a rat model of myocardial infarction (MI), Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, alleviates fibrosis in the noninfarcted regions. Furthermore, it delays left ventricular remodeling and the progression of heart failure in the MI rat model[3].
AliasSQ19844 ammonium, Cholecystokinin octapeptide ammonium, CCK-8 ammonium
Chemical Properties
Molecular Weight1160.3
FormulaC49H65N11O16S3
Cas No.70706-98-8
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 30 mg/mL, Sonication is recommended.

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